Don't forget to up-vote the question or answer if you find it helpful! If it's your own question and you're very happy with an answer you can accept it as best answer.
I keep getting this message when I try to start Protools...
"Protools could not initialize current playback device. Please make sure the device has been configured correctly".
I can't understand why it now has trouble identifying my my mbox 2. Logic can see it, reason as well.
Have you done any recent updates? Also, what OS and version of Pro Tools are you running? I've encountered this problem in a variety of ways. Sometimes I've even gotten this error after a flash drive pulled out without ejecting. When this happens in OSX 10.6.x, it causes permissions errors that severely affect Pro Tools 8. Disk Repair usually will do the trick for that. Also, the MBox2's require newer drivers, so if you haven't updated the drivers, you might also try that. The first thing I usually will try is a computer restart. I'm assuming you probably tried that (and probably some other stuff as well). Also, if you get totally stuck go to the DUC (avid.duc.com). Search your error and chances are, you'll find an answer--most likely from Avid.
Please note: When commenting on someone's question or answer, you will not receive notification on follow up comments unless you are mentioned with @Username. So for Andrew Spitz, you only need to use @Andrew